Officers believe the two men in the images may have witnessed the incident but have not yet come forward.
Detective Chief Inspector Brian Howie, from the Met's Specialist Crime Command, said: "If you are the people in these images, or if you know who they are, then I urge you to please get in touch with us.
"I'd like to stress that you are not in any trouble. We believe that you may have important information relating to the brutal murder of Adrian outside the Cubana restaurant. Please, do the right thing and contact my team today – or if you'd prefer to stay anonymous then contact the independent charity Crimestoppers."
Police were called at 2.15am on Saturday 29 October 2022 to reports of a stabbing outside the Cubana Restaurant on Lower Marsh, SE1.
Police officers attended along with paramedics from the London Ambulance Service. It was reported that a 32-year-old had been stabbed.
Adrian Keise was found at about 2.30am near to a block of flats on Frazier Street. He was treated at the scene before being taken to hospital. Despite the efforts of emergency services, he died a short time later.
A post-mortem examination gave the cause of death as stab injuries.
Anyone who recognises the people in the photos, or has information that could help the investigation, is asked to call police on 101 quoting CAD 681/29Oct22.
You can also share information, photos and videos directly with the investigation team.